Patents and Publications

Patents

EP22160310: Microorganism strain for antibiotic-free plasmid-based fermentation and method for generation thereof, 04 March 2022
EP21174990: Microorganism strain and method for antibiotic-free plasmid-based fermentation, 20 May 2021

Recent Talks and Poster Contributions

  • Poster: “E. coli Conji – One strain for all: Plasmid cloning and mobilization”, German Conference on Synthetic Biology, Münster 2026
  • Poster: “Antibiotic-Free Fermentation: Plasmid maintenance without antibiotics or antibiotic resistance genes”, German Conference on Synthetic Biology, Münster 2026
  • Talk: “𝗔𝗻𝘁𝗶𝗯𝗶𝗼𝘁𝗶𝗰-𝗳𝗿𝗲𝗲 𝗽𝗹𝗮𝘀𝗺𝗶𝗱 𝘀𝗲𝗹𝗲𝗰𝘁𝗶𝗼𝗻 𝗮𝗻𝗱 𝗺𝗮𝗶𝗻𝘁𝗲𝗻𝗮𝗻𝗰𝗲 𝘃𝗶𝗮 𝗶𝗻𝗱𝘂𝗰𝗶𝗯𝗹𝗲 𝗰𝗼𝗺𝗽𝗹𝗲𝗺𝗲𝗻𝘁𝗮𝘁𝗶𝗼𝗻”, Recombinant Protein Production: RPP12, Ulm 2025
  • Poster: “Antibiotic-Free Fermentation Plasmid maintenance without antibiotics or antibiotic resistance genes”, HIT2025 – Himmelfahrtstagung on Bioprocess Engineering, Bremen 2025
  • Poster: “E. coli conji pir+: For plasmid cloning and mobilization in one strain”, International Rhodobacter Symposium, Wageningen 2025
  • Poster: “Novel Technologies for Optimizing Speed and Quality of Custom Transgenic Mouse Models”, American Society of Human Genetics ASHG Annual Meeting, Boston 2025
  • Talk: “Antibiotic-free plasmid maintenance based on complementation of a conditionally repressed essential gene”, VAAM, Göttingen 2024
  • Poster: “Introducing OzBIG: A robust process for generating mouse models with 20 – 240 kb targeted replacement”, ISTT, Helsinki, 2022

Publication

  • Inducible complementation for antibiotic-free plasmid-based biomanufacturing in industrially relevant strains; Katherine E. Brechun, Marion Förschle, Marlen Schmidt and Harald Kranz, Ind. Microbiol., 2026; https://doi.org/10.3389/finmi.2025.1725733
  • Selective silencing of antibiotic-tethered ribosomes as a resistance mechanism against aminoglycosides; Nilanjan Ghosh Dastidar, Nicola S. Freyer, Valentyn Petrychenko, Ana C. de A. P. Schwarzer, Bee-Zen Peng, Ekaterina Samatova, Christina Kothe, Marlen Schmidt, Frank Peske, Antonio Z. Politi, Henning Urlaub, Niels Fischer, Marina V. Rodnina & Ingo Wohlgemuth; Nature Communications 2025; 16:9568; https://doi.org/10.1038/s41467-025-65298-7
  • On subcellular distribution of the zinc finger 469 protein (ZNF469) and observed discrepancy in the localization of endogenous and overexpressed ZNF469; Anne Elisabeth Christensen Mellgren, Ileana Cristea, Thomas Stevenson, Endy Spriet, Per Morten Knappskog, Stig Ove Bøe, Harald Kranz, Sushma N. Grellscheid and Eyvind Rødahl, FEBS Open Bio, 2025, 15, 1054
  • Method for plasmid-based antibiotic-free fermentation; Katherine E. Brechun, Marion Förschle, Marlen Schmidt and Harald Kranz; Microbial Cell Factories 2024; 23:18
  • Application of an Escherichia coli triple reporter strain for at-line monitoring of single-cell physiology during L-phenylalanine production; Mahn Dat Hoang, Dieu Thi Doan, Marlen Schmidt, Harald Kranz, Andreas Kremling and Anna-Lena Heins; Eng Life Sci 2022, 1
  • Novel Escherichia coli active site dnaE alleles with altered base and sugar selectivity; Alexandra Vaisman, Krystian Łazowski, Martin A. M. Reijns, Erin Walsh, John P. McDonald, Kristiniana C. Moreno, Dominic R. Quiros, Marlen Schmidt, Harald Kranz, Wei Yang, Karolina Makiela-Dzbenska and Roger Woodgate; Molecular Microbiology 2021; 116: 909
  • CroSR391, an ortholog of the λ Cro repressor, plays a major role in suppressing polVR391-dependent mutagenesis; John P. McDonald, Dominic R. Quiros, Alexandra Vaisman, Antonio R. Mendez, Jan Reyelt, Marlen Schmidt, Martín Gonzalez and Roger Woodgate; Molecular Microbiology 2021, 116: 877
  • Development and characterization of Escherichiacoli triple reporter strains for investigation of population heterogeneity in bioprocesses; Anna-Lena Heins, Jan Reyelt, Marlen Schmidt, Harald Kranz and Dirk Weuster-Botz; Microbial Cell Factories 2020, 19: 14
  • Common schizophrenia risk variants are enriched in open chromatin regions of human glutamatergic Neurons; Mads E. Hauberg, Jordi Creus-Muncunill, Jaroslav Bendl, Alexey Kozlenkov, Biao Zeng, Chuhyon Corwin, Sarah Chowdhury, Harald Kranz, Yasmin L. Hurd, Michael Wegner, Anders D. Børglum, Stella Dracheva, Michelle E. Ehrlich, John F. Fullard and Panos Roussos; Nature Communications; 2020; 11: 5581

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